The End Up
401 6th St, SOMA
415 896 1075 YELP
A San Francisco tradition since 1973. Great music, great gay/mixed crowd.

Ruby Skye
420 Mason St, Union Square
415 693 0777 YELP
International DJs, enormous dance floor, VIP lounges. Straight/gay.

111 Minna
111 Minna, SOMA
415 974 1719 YELP
Bar, gallery and club with hip, urban clientele. Mixed.

Pink
2925 16th St, The Mission
415 625 8880 YELP
Intimate Euro-style club with fab DJ lineup. Straight-ish.